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I am willing to bet most of the people that come across this blog remember a time when you took organic chemistry. While I do not find this topic particularly interesting, mass spectrometry was briefly touched upon. This is an analytical tool that measures the mass of different molecules within a sample by measuring their
If you get nothing from this, just remember: TMP-SMX, fluroquinolones, minocycline. These tend to be good antibiotic options for this bug. Also, make sure if you isolate this from a trach or a endotracheal tube that there are signs of infection before you proceed with treatment as this can colonize plastic! Stenotrophomonas maltophilia is a
Staphylococcus aureus bacteremia is a cause of severe morbidity and mortality, especially when it is complicated by infective endocarditis. The mortality of Staphylococcus aureus bacteremia is 20% (1) and that of infective endocarditis due to Staph aureus is much higher. Guidelines for the treatment of MRSA SAB (2) recommends the use of echocardiography, with TEE
So why speak about these 2 topics on the same post? Because they’re essentially the same disease; they are parasites that have a predilection for red blood cells and lead to hemolysis and other symptoms. Further, their diagnosis is similar as are their therapeutics. In other words, Babesia is the North American Malaria. Which is
This is a difficult post to go over since there is so much data to comb through that will likely change as the years go by (as with any topic I write about, but more so about therapy for influenza). Stay tuned as the flu season comes upon us, as this post may be updated
Strongylodiasis is probably one of those disease you don’t think about. After all, it is generally thought to be a tropical infectious disease, and as a result, there is little Western familiarity with it. While the number of infected people worldwide ranges from 30-100 million (1), with a recent review noting the prevalence being 10-40%
Enterococcal infections and bacteremia incidence have been increasing over the past decades, with enterococcal endocarditis representing 10% of all cases of infective endocarditis (1). This makes it the third most common organism implicated in IE, after Staphylococcus and streptococcus, and it is more prevalent in patients who are not drug abusers. Enterococcal bacteremia by itself
Beta-Lactamases make my head hurt. They are so many of them and they impact the therapeutic options for a lot of the infections that we treat. Due to this resistance mechanism, there has been an influx of new beta-lactam/beta-lactamase combinations (ceftazidime-avibactam, meropenem-vaborbactam, etc) to overcome this phenomena. So first, this is a beta-lactam: The penicillin-binding
Last week I talked about invasive pulmonary aspergillosis in influenza and COVID patients. This is not the first time I have talked about this topic. I have mentioned how the halo sign is not terribly specific for IPA, especially in hematological patients and the testing characteristics of galactomannan. I have also spoken about the other
Influenza season is right around the corner, and given the current circumstances, it is a terrifying thought to have both COVID and flu running around. Besides causing significant respiratory distress and subsequent ARDS, severe influenza leads to bacterial superinfection with organisms such as Staph aureus and Streptococcal pneumonia. This usually happens in 10-35% of cases
Dr. Germophile 