Ditte Marie Kirkegaard-Klitbo, Magda Teresa Thomsen, Marco Gelpi, Flemming Bendtsen, Susanne Dam Nielsen, Thomas Benfield, Hepatic steatosis associated with exposure to elvitegravir and raltegravir, Clinical Infectious Diseases, 2021;, ciab057, https://doi.org/10.1093/cid/ciab057 This was an observational cohort study evaluating exposure to integrase inhibitors and subsequent hepatic steatosis. As it is known, integrase inhibitors are associated with increased
Month: January 2021
What do we want? More nec fasc! When do we want it? Now! Perhaps not a lot of people really want necrotizing fasciitis (see here), though to be fair, this post is not entirely about necrotizing fasciitis. In fact, this deals more with the “super saiyan” antigens, those toxins that group A strep and some
When I say bat poop, caves, and Indiana, the answer is Histoplasmosis. In general, most people will not get disease even when inhaling any conidia, however those who have decreased cellular immunity (i.e. solid organ transplant and HIV) are at risk of pulmonary or disseminated disease. One of the difficult issues in those patients is
Hyperbaric oxygen therapy involves breathing 100% oxygen at a higher atmospheric pressure (usually 2.5-3 atm) and it has recently been widely used for multiple diseases. Recall Boyle’s law: Increasing pressure decreases the volume, so pressurizing the human body causes a decrease in volume of gas-filled spaces (1). As such, it has clinical uses in arterial
If you are reading this, I am sure you are aware of C. diff. You have either thought about it in patients who are getting antibiotics and have diarrhea, groaned at the fact you have to don PPE when “ruling out” C. diff, or had a horrible experience (perhaps not personal) where things went south
Happy new year, it feels like 2021 is trying to give 2020 a run for its money. Oh boy! Anyways, some COVID stuff since we’re over 4000 deaths a week here in the states. Oussalah A, Gleye S, Clerc Urmes I, Laugel E, Callet J, Barbé F, Orlowski S, Malaplate C, Aimone-Gastin I, Caillierez BM,
Invasive mold infections tend to arise in patients who are profoundly immunosuppressed. Recently, those with COVID and severe influenza have been found to have a significant risk for these infections, but I will not focus on these. Instead, I will focus on those who lack that “first line of defense” i.e those who are neutropenic
I have been hesitant about posting anything related to influenza vaccines. This is in part because the data changes from season to season, and the amount of literature that comes out is staggering (seriously, take a look at pubmed and you will see what I mean). Further, there seems to be a lot of misinformation
Blood cultures are typically drawn in patients who present with sepsis due to concern for infection. While the trigger response to “fevers and leukocytosis” is to obtain blood cultures, the positive rate that has been quoted ranges from 4-7% (1), depending on the source. Indeed, blood culture contamination is a frequent problem that is encountered
Dr. Germophile 