Month: December 2020

The Lyon Heart – The Virulent Coagulase-Negative Staphylococcus

Coagulase negative staphylococcus are generally skin commensals we tend to ignore when they pop up in one set of blood cultures as they tend to represent contamination of the blood culture bottles rather than true bacteremia. The most commonly seen is Staphylococcus epidermidis. The reason they are called “coagulase negative staphylococcus” is these organisms, compared

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Weekly Articles: 12/27/2020

George R Thompson, III, Alex Soriano, Athanasios Skoutelis, Jose A Vazquez, Patrick M Honore, Juan P Horcajada, Herbert Spapen, Matteo Bassetti, Luis Ostrosky-Zeichner, Anita F Das, Rolando M Viani, Taylor Sandison, Peter G Pappas, Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive Candidiasis- The STRIVE Trial,

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Hansen’s Disease – Leprosy

Leviticus 13:45-13:46 – And the leper in whom the plague [is], his clothes shall be rent, and his head bare, and he shall put a covering upon his upper lip, and shall cry, Unclean, unclean. All the days wherein the plague [shall be] in him he shall be defiled; he [is] unclean: he shall dwell

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Actinomycoses Infections

Unlike some of my previous recent posts (read: Leishmania, Hantavirus), I think this one is of value. The reason being this bug is not thought of (outside of medical school, when it is learned with Nocardia). Most of the time, this infection is diagnosed by the pathologist, after a surgery to remove what is thought

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What is the deal with Visceral Leishmaniasis?

Visceral leishmaniasis is a protozoan disease caused by the Leishmania donovani complex, which is transmitted by sand flies in the genus phlebotomus in the old world and Lutzomyia in the new world (1). Leishmaniasis tends to be an intracellular organism, infecting macrophages and the reticuloendothelial system, leading to severe bone marrow suppression and splenomegaly. The

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Weekly Articles of 12/13/2020

COVID-19 Articles Its been a while since I’ve talked about COVID. Anyways. Lenze EJ, Mattar C, Zorumski CF, et al. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020;324(22):2292–2300. doi:10.1001/jama.2020.22760 Fluvoxamine is an SSRI which has an affinity towards S1R which regulates cytokine production. This was a

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Weekly Articles: Week of 12/6/2020

Ighovwerha Ofotokun, Lauren F Collins, Kehmia Titanji, Antonina Foster, Caitlin A Moran, Anandi N Sheth, Cecile D Lahiri, Jeffrey L Lennox, Laura Ward, Kirk A Easley, M Neale Weitzmann, Antiretroviral Therapy–Induced Bone Loss Is Durably Suppressed by a Single Dose of Zoledronic Acid in Treatment-Naive Persons with Human Immunodeficiency Virus Infection: A Phase IIB Trial,

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Infections associated with Strep Milleri Group – Pus Galore

The group streptococcus anginosis or milleri consist of 3 types of streptococci. These include Streptococcus intermedius, Streptococcus constellatus, and streptococcus anginosus and they are usual colonizers of the oropharygneal, urogenital, and gastrointestinal tract and tend to cause pyogenic infections (i.e. abscesses, 1). While I mentioned in a previous post that I tend to think of

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Classification of Streptococci

I am of the opinion (as is my idol, Mark Crislip) that microbiologists get together every few years, get drunk, and re-organize and re-classify microorganisms (its not like that, but Id like to believe this is the case). Streptococcus is one of those families of organisms that is difficult to organize in someone’s head, especially

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Daptomycin vs Linezolid for Vancomycin-Resistant Enterococcus

I’ve previously discussed how much more difficult Enterococcal infections are to treat when compared to other bacteria such as streptococci. This stems from the fact these bacteria have tend to be more resistant to beta-lactam antibiotics, with synergy being the name of the game for serious infections with these bacteria (in general, ampicillin/ceftriaxone). This is

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