Month: June 2021

The Antibiotic Nightmare – M. Abscessus

Mycobacterium abscessus therapy is kind of a crapshoot. It is unfortunate to say it like that yet the resistance profiles for this complex of mycobacteria and the microbiology of it make it a frustrating organism to treat. This organism has been called an “antibiotic nightmare” for multiple reasons.  Let’s start here. M. abscessus (as I

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PJP in AIDS-Patients vs non-AIDS Patients

Consider this post a continuation of the prior one on prophylaxis. I mention a bit on the pathophysiology, where adaptive immunity seems to play a key role in the way the body deals with the fungus, with mice with SCID infected with pneumocystis not being able to mount an inflammatory response. As a result of

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PJP Prophylaxis in Rheumatological Disease – Do You Need it? Probably

First identified by Carlos Chagas (yes, that Chagas) back in 1909, pneumocystis was identified as a cause of plasma cell pneumonia in debilitated infants following WWII (1). Since then, it has been identified as a unicellular fungus that is of low virulence and unique amongst the other fungi in that it lacks ergosterol in its

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