Tag: hematology

Crash and Burn: CMV Pneumonitis in Hematological Malignancies

What is this? I am writing about a topic related to transplant infectious diseases? Something has to be going on! I had originally intended to write about CMV serostatus and risk of organ rejection in SOT patients, but that was a more difficult topic to tackle (just like that HTLV-1 post; yeah that one is

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Halo Sign for Pulmonary Aspergillosis – Not as Great as You Once Thought.

The timely diagnosis of invasive pulmonary aspergillosis is incredibly important. Non-invasive modalities of diagnosis such as beta-D glucan and galactomannan can take a few days to come back and much of the time, we rely on chest imaging to guide treatment decision. The classic finding that has been attributed to invasive pulmonary aspergillosis has been

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Chang, Euijin, et al. “Limited Positive Predictive Value of β-d-Glucan in Hematologic Patients Receiving Antimold Prophylaxis.” Open Forum Infectious Diseases, vol. 7, no. 3, 2020, pp. ofaa048.

Retrospective study from South Korea evaluating the predictive value of BD glucan in the age of mold active triazole prophylaxis. They recruited patients that underwent induction chemotherapy, SCT, or GVHD treatment that had BD glucans throughout their stay while on posa or micafungin prophylaxis. They defined a positive BD glucan as 2 or more BDG

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