Literature review on any “old timey” organism can be kind of a pain since I am convinced microbiologists get drunk every so often to reclassify clinically relevant organisms. This is the case for Bartonella. Originally described as bartonia, which is an erythrocyte-adherent organism similar to organisms of the genus of Rochalimacae, including Rickettsia quintana, was
During residency, I had the opportunity to do a global health elective where I spent a month in Lima, Peru rotating through Cayetano. I spent the majority of the time in the Tropical Medicine ward, where tuberculosis was everywhere. One of the more vivid memories was a patient with AIDS and cryptococcal meningitis. The residents
HIV therapy has undergone many iterations. Long gone are the days of AZT and semi-literal drug cocktails and we have entered into an era where HIV treatment is as easy as just getting one pill per day with Triumeq, Biktarvy, and Atripla which include three-active components. Newcomer, Cabotegravir, may change the game going forward as
As it so happens, someone much smarter than me has already written on this topic, so check out Paul Sax’s post: https://blogs.jwatch.org/hiv-id-observations/index.php/the-curious-case-of-m184v-part-2-and-more/2019/09/08/ There is no doubt that anti-retroviral therapy has been one of the greatest accomplishments in HIV care. Nowadays, HIV is essentially a chronic disease that is easily managed with combined therapy, usually with
Mehraj, Vikram, et al. “Circulating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection.” Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 70, no. 2, 2020, pp. 232-241.
This is a cross-sectional and longitudinal assessment of BD glucan levels in 146 patients living with HIV. Within this cohort, 53 had been diagnosed within 6 months, 22 had chronic HIV but no ART, and 71 had chronic HIV and were on ART. These were then compared to 42 uninfected controls. The study design is