Category: Antibiotics

Staphylococcus Aureus, the Inoculum Effect, Cefazolin, and Nafcillin: The Odyssey

Staphylococcus Aureus is a tough disease to treat, but luckily for MSSA we have pretty good antibiotics to treat this beast. The choice is usually between cefazolin, a first-generation cephalosporin, and Nafcillin, an anti-staphylococcal penicillin. My experience has been that cefazolin is usually the go to antibiotic for MSSA bacteremia, with nafcillin having a niche

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Dual Therapy for MRSA Bacteremia – We Still Haven’t Figured it out

So MRSA is really hard to kill. If you have done any sort of ID, you will not be surprised by that statement. MRSA bacteremia has a high relapse rate. Because of this, people have tried multiple types of antibiotics, including Daptomycin and Ceftaroline, have been used with minimal change in the outcomes. In the

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Surgery in Native Valve Infective Endocarditis

In general, this tends to be a tricky subject. Add that to the fact that there are varying recommendations from different societies, it becomes difficult to figure out the who and when (I assume the surgeons will figure out the how). Here, we will look at timing of surgical intervention in left sided native infective

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On to Plague

The history of plague and its place in human history is difficult to argue. There are 3 major pandemics that are attributed to the organism Yersinia Pestis: The “Justinian” Plague during the Byzantine Empire The “Black Death” during Medieval Europe The “Third Pandemic” that began in the late 19th Century and likely ongoing until today

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Vertebral Osteomyelitis – Length of Therapy

The duration of therapy in vertebral osteomyelitis tends to be prolonged, usually 6 weeks of more. If there is anything to take away from this, is that at least 6 weeks of antibiotics for vertebral osteomyelitis is usually fine, but there are certain exceptions that may warrant longer duration of therapy. Some well cited data

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