Where all your ID needs are met! Sort of.
Gram negatives are a nightmare. Or at least, they are becoming a nightmare with all new patterns of resistance, beta-lactamases and carbapenamases, and plasmid-encoded resistances bringing forth the new generation of beta-lactam and beta-lactamase combinations that I find difficult to keep up with. The definitions of multi-drug resistant organisms tend to be more geared towards
I meant to write about HTLV-1 tropical spastic paraparesis, however halfway through reading the papers I realized I bit more than I could chew. This is likely due to the fact I am awful with neurology (despite being a neuro major in college) and my lack of familiarity with tropical medicine. Needless to say, that
A bit late on this one but I have some info on the delta variant. Lustig Y, Zuckerman N, Nemet I, Atari N, Kliker L, Regev-Yochay G, Sapir E, Mor O, Alroy-Preis S, Mendelson E, Mandelboim M. Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care
Surial B, Mugglin C, Calmy A, Cavassini M, Günthard HF, Stöckle M, Bernasconi E, Schmid P, Tarr PE, Furrer H, Ledergerber B, Wandeler G, Rauch A; Swiss HIV Cohort Study. Weight and Metabolic Changes After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in People Living With HIV : A Cohort Study. Ann Intern Med.
Mycobacterium abscessus therapy is kind of a crapshoot. It is unfortunate to say it like that yet the resistance profiles for this complex of mycobacteria and the microbiology of it make it a frustrating organism to treat. This organism has been called an “antibiotic nightmare” for multiple reasons. Let’s start here. M. abscessus (as I
Consider this post a continuation of the prior one on prophylaxis. I mention a bit on the pathophysiology, where adaptive immunity seems to play a key role in the way the body deals with the fungus, with mice with SCID infected with pneumocystis not being able to mount an inflammatory response. As a result of
First identified by Carlos Chagas (yes, that Chagas) back in 1909, pneumocystis was identified as a cause of plasma cell pneumonia in debilitated infants following WWII (1). Since then, it has been identified as a unicellular fungus that is of low virulence and unique amongst the other fungi in that it lacks ergosterol in its
Some isavuconazole news, a PJI trial, a few HIV-related articles, and therapies for COVID that won’t die. Maertens JA, Raad II, Marr KA, Patterson TF, Kontoyiannis DP, Cornely OA, Bow EJ, Rahav G, Neofytos D, Aoun M, Baddley JW, Giladi M, Heinz WJ, Herbrecht R, Hope W, Karthaus M, Lee DG, Lortholary O, Morrison VA,
Quite a few here. A brief word on the new vancomycin dosing guidelines, dual therapy for enterococcal IE and MRSA bacteremia, and several updates on COVID-19. Anna Poston-Blahnik, Ryan Moenster, Association Between Vancomycin Area Under the Curve and Nephrotoxicity: a single center, retrospective cohort study in a veteran population, Open Forum Infectious Diseases, Volume 8,
Staphylococcus aureus is an organism that is quite common in many diseases, including skin and soft tissue infections, bacteremias, and pneumonia. It causes fairly severe infection due to its significant number of toxins and virulence factors. I have mentioned the superantigen that causes toxic shock syndrome however another toxin that is useful to know about
Dr. Germophile 