Albin OR, Henig O, Patel TS, Valley TS, Pogue JM, Petty LA, Mills JP, Brancaccio A, Martin ET, Kaye KS. Clinical Implications of Microbiologic Treatment Failure in the Setting of Clinical Cure of Bacterial Pneumonia. Clin Infect Dis. 2020 Dec 15;71(12):3033-3041. doi: 10.1093/cid/ciz1187. PMID: 31832641; PMCID: PMC7819508. This is a retrospective study of 441 patients
Category: Article Summaries
Well hello there. I took too long of a break but I am back for some more articles to report on. Up up and away! Prior to writing about these articles, let’s take a step back and figure out what cefiderocol is. This is a new cephalosporin (a siderophore, if you will) that has broad
Ditte Marie Kirkegaard-Klitbo, Magda Teresa Thomsen, Marco Gelpi, Flemming Bendtsen, Susanne Dam Nielsen, Thomas Benfield, Hepatic steatosis associated with exposure to elvitegravir and raltegravir, Clinical Infectious Diseases, 2021;, ciab057, https://doi.org/10.1093/cid/ciab057 This was an observational cohort study evaluating exposure to integrase inhibitors and subsequent hepatic steatosis. As it is known, integrase inhibitors are associated with increased
Happy new year, it feels like 2021 is trying to give 2020 a run for its money. Oh boy! Anyways, some COVID stuff since we’re over 4000 deaths a week here in the states. Oussalah A, Gleye S, Clerc Urmes I, Laugel E, Callet J, Barbé F, Orlowski S, Malaplate C, Aimone-Gastin I, Caillierez BM,
George R Thompson, III, Alex Soriano, Athanasios Skoutelis, Jose A Vazquez, Patrick M Honore, Juan P Horcajada, Herbert Spapen, Matteo Bassetti, Luis Ostrosky-Zeichner, Anita F Das, Rolando M Viani, Taylor Sandison, Peter G Pappas, Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive Candidiasis- The STRIVE Trial,
COVID-19 Articles Its been a while since I’ve talked about COVID. Anyways. Lenze EJ, Mattar C, Zorumski CF, et al. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020;324(22):2292–2300. doi:10.1001/jama.2020.22760 Fluvoxamine is an SSRI which has an affinity towards S1R which regulates cytokine production. This was a
Ighovwerha Ofotokun, Lauren F Collins, Kehmia Titanji, Antonina Foster, Caitlin A Moran, Anandi N Sheth, Cecile D Lahiri, Jeffrey L Lennox, Laura Ward, Kirk A Easley, M Neale Weitzmann, Antiretroviral Therapy–Induced Bone Loss Is Durably Suppressed by a Single Dose of Zoledronic Acid in Treatment-Naive Persons with Human Immunodeficiency Virus Infection: A Phase IIB Trial,
Morgan DJ, Zhan M, Goto M, Franciscus C, Alexander B, Vaughan-Sarrazin M, Roghmann MC, Pineles L. The Effectiveness of Contact Precautions on Methicillin-Resistant Staphylococcus aureus in Long-term Care Across the United States. Clin Infect Dis. 2020 Oct 23;71(7):1676-1683. doi: 10.1093/cid/ciz1045. PMID: 31637429. This was a cohort study of long-term VA facilities (aka the CLC) evaluating
In the past few years, there has been an increasing in the incidence of hypeviscous Klebsiella pneumoniae. This is typically caused by phenotypes associated with K1 and K2 capsule serotypes and is seen in southeast Asia and the classical pathology is that of a liver abscess (why this is I do not know). Recently, a
Tamma PD, Conley AT, Cosgrove SE, et al. Association of 30-Day Mortality With Oral Step-Down vs Continued Intravenous Therapy in Patients Hospitalized With Enterobacteriaceae Bacteremia. JAMA Intern Med. 2019;179(3):316–323. doi:10.1001/jamainternmed.2018.6226 This is a multicenter retrospective cohort on patients with monomicrobial Enterobacteriacae blood stream infections (Citrobacter spp, Enterobacter spp, E.coli, Klebsiella spp, Proteus mirabilis, or Serratia marcecens) comparing
Dr. Germophile 